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In the new review, we claimed the identification as well as the characterization of a different atypical opioid receptor with unique detrimental regulatory Homes towards opioid peptides.one Our effects confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is likewise a broad-spectrum scavenger